Cardiac cachexia

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Cardiac cachexia: hic et nunc

Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been challenged, more precisely, the addition of new criteria on top of obligatory weight loss. The pathophysiology of CC is complex and multifactorial. A better understanding of pathophysiological pathways in b...

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Cardiac cachexia: a systematic overview.

Cardiac cachexia as a terminal stage of chronic heart failure carries a poor prognosis. The definition of this clinical syndrome has been a matter of debate in recent years. This review describes the ongoing discussion about this issue and the complex pathophysiology of cardiac cachexia and chronic heart failure with particular focus on immunological, metabolic, and hormonal aspects at the intr...

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Cardiac Cachexia: Pathophysiology and Clinical Implications

Cardiac cachexia (i.e. body wasting) has long been recognised as a serious complication of chronic heart failure (CHF) which affects many body systems and remains an important and increasing public health problem. The occurrence of wasting in CHF has been known for many centuries but little investigated. Independently of functional disease severity, age, and measures of exercise capacity and ca...

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Cardiac Cachexia: Perspectives for Prevention and Treatment

Cachexia is a prevalent pathological condition associated with chronic heart failure. Its occurrence predicts increased morbidity and mortality independent of important clinical variables such as age, ventricular function, or heart failure functional class. The clinical consequences of cachexia are dependent on both weight loss and systemic inflammation, which accompany cachexia development. Sk...

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Cardiac alterations in cancer-induced cachexia in mice.

Cachexia is a common syndrome in advanced cancer patients and causes up to 22% of cancer-related deaths. It remains elusive whether cancer cachexia causes heart failure. We investigated the effect of cancer cachexia on heart function and cardiac muscle structure in a mouse model. Male CD2F1 mice were inoculated with either colon-26 adenocarcinoma cells (Tumor group) or vehicle (PBS) (No Tumor g...

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ژورنال

عنوان ژورنال: Indian Heart Journal

سال: 2015

ISSN: 0019-4832

DOI: 10.1016/j.ihj.2015.10.245